House is serving a prison sentence for driving his car into Cuddy's living room, and when his sentence ends early, he finds the Diagnostic Medicine Department has gone through a transition in his absence and he must deal with a new chain of command and personnel changes to his team.

He's sarcastic, incorrigible, bitter, and in a relationship? Dr. Gregory House has spent his career taking on seemingly hopeless cases, but when his rapport with Dr. Lisa Cuddy changes, he finds himself facing new, and very different, challenges. His team at Princeton-Plainsboro Teaching Hospital also continues to blaze trails as they investigate baffling medical cases involving a religious zealot, a professional bull rider, and possibly even smallpox....

Dr. Gregory House is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain and ignoring his pain-killing addiction, he uses his cane to punctuate his acerbic, brutally honest demeanor. House and his team deal with unusual medical mysteries.

"Dr. Gregory House still has the most unapologetically prickly bedside manner ever, but his genius for solving the medical mysteries other practitioners can't has earned him the respect of his team. House's unpredictable cases, from killer germs to killer secrets, strain his already tenuous relationship with his co-workers and put his own health at risk."--Container.