When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.

Irrepressible friends Jorge and Berto create a new comic book superhero, Superbebé Pañal. Jorge Betanzos y Berto Henares son dos chicos fenomenales. No solo han creado al Capitán Calzoncillos, sino que también ¡han salvado al mundo cinco veces! Ahora nos traen a un nuevo héroe que es más veloz que un cochecito de bebé sin frenos, más poderoso que la irritación que causan los pañales y capaz de saltar de un rasacielos a otro sin hacerse...

When George and Harold hypnotize their principal into thinking that he is the superhero Captain Underpants, he leads them to the lair of the nefarious Dr. Diaper, where they must defeat his evil robot henchmen.

Having changed the course of human history after unwittingly wondering what could be worse than going to prison, George and Harold are shot through time back to kindergarten, where they are subjected to bullying and a clueless school principal.

Harold and George's time-traveling Purple Potty lands them in an alternate universe where everything seems delightful, but evil lurks just beneath the surface, and leads to a battle between Captain Underpants and his own evil twin.

Por burlarse del nombre del profesor Pipicaca, Jorge y Beto están a punto de hacer que su nuevo maestro de ciencia enloquecido de rabia se apodere del planeta entero. Pero Capitán Calzoncillos viene al rescate. When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous...